Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 2, pp 809–811 | Cite as

Variation in antiinfectious nonspecific resistance of the organism caused by cholinergic stimulation

  • P. F. Zabrodskii
Pharmacology and Toxicology

Abstract

Cholinergic stimulation (acetylcholine, aceclidine, armin) is found to improve antiinfectious nonspecific resistance in mice. The effect depends on the dose of cholinomimetic (armin), is maximal during the first 18 hours of the infectious process, and is determined by serum antibacterial activity, lysozyme activity, and the function of neutrophils and natural killers.

Key Words

cholinergic stimulation antiinfectious resistance nonspecific factors of the organism's resistance natural cytotoxicity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    I. A. Gontova, V. V. Abramov, N. Yu. Gromykhina,et al., Immunologiya, No 4, 52–55 (1989).Google Scholar
  2. 2.
    S. M. Gordienko,, No 1, 31–36 (1984).Google Scholar
  3. 3.
    P. P. Denisenko, in:The Role of Cholinergic Systems in Regulatory Processes [in Russian], Moscow (1980), pp. 165–195.Google Scholar
  4. 4.
    P. F. Zabrodskii and V. N. Kazakov,Zh. Mikrobiol., No 2, 32–36 (1988).PubMedGoogle Scholar
  5. 5.
    Evaluation of the Immunological Status of the Organism in Soviet Army and Navy Medical Institutions (Manual) [in Russian], Moscow (1987).Google Scholar
  6. 6.
    B. H. Dulis, M. A. Gordon, and I. B. Wilson,Mol. Pharmacol.,15, No 1, 28–34 (1979).PubMedGoogle Scholar
  7. 7.
    J. Ferluga, G. L. Asherson, and E. L. Becker,Immunology,23, No 4, 577–590 (1972).PubMedGoogle Scholar
  8. 8.
    E. Grabczeowska, H. Lakowska-Bozek, W. Maslinski, and J. Ryzewsri,Rheumatology,28, No 4, 170–179 (1990).Google Scholar
  9. 9.
    C. Y. Li, K. W. Lam, and L. T. Yam,J. Histochem. Cytochem.,21, No 1, 1–12 (1973).PubMedGoogle Scholar
  10. 10.
    A. Loran,Lancet, No 8816, 420–421 (1992).Google Scholar
  11. 11.
    G. Millington and J. C. Buckingam,J. Endocr.,133, No 2, 163–168 (1992).PubMedCrossRefGoogle Scholar
  12. 12.
    J. M. Quiroz and L. A. Oliveina,Rev. Brasil. Pesquesis Med. Biol.,8, No 2, 119–123 (1975).Google Scholar
  13. 13.
    I. Rinner and K. Schauenstein,J. Neuroimmunol.,34, No 2-3, 165–172 (1991).PubMedCrossRefGoogle Scholar
  14. 14.
    H. Techima, H. Sodama, H. Kihara, and T. Nakagama,Fukuoka Acta Med.,82, No 7, 428–436 (1991).Google Scholar
  15. 15.
    J. F. Whitfield, J. P. MacManus, H. R. Rixon,et al., In Vitro Cell. Dev. Biol,12, No 1, 1–18 (1976).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • P. F. Zabrodskii
    • 1
  1. 1.Department of ToxicologySaratov Medical UniversitySaratovUSSR

Personalised recommendations