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Effects of methyluracil and hydroxymethacil on free-radical oxidation in model systems

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Three pyrimidine derivatives — methyluracil, hydroxymethacil (a new compound), and its lithium salt — were tested in model systems of differing complexity for antioxidant properties in comparison with the well-known antioxidant ionol. Tests for antiradical activity and for effects on spontaneous and Fe2+-ascorbate- or NADPH-dependent lipid peroxidation revealed high antioxidant activity (comparable to that of ionol) of the hydroxymethacil lithium salt.

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Authors and Affiliations

  1. Beshkir Medical Institute, Ufa

    V. A. Myshkin, Z. G. Khaibullina, S. A. Bashkatov, V. P. Krivonogov & D. A. Enikeev

Authors
  1. V. A. Myshkin
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  2. Z. G. Khaibullina
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  3. S. A. Bashkatov
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  4. V. P. Krivonogov
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  5. D. A. Enikeev
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, No 8, pp. 142–144, August, 1995

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Myshkin, V.A., Khaibullina, Z.G., Bashkatov, S.A. et al. Effects of methyluracil and hydroxymethacil on free-radical oxidation in model systems. Bull Exp Biol Med 120, 785–788 (1995). https://doi.org/10.1007/BF02445953

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  • DOI: https://doi.org/10.1007/BF02445953

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