Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 2, pp 774–778 | Cite as

Effect of substance P on neurological status and behavioral responses altered as a result of prolonged brain ischemia in rats with different types of behavior

  • K. Yu. Sarkisova
  • I. A. Kolomeitseva
  • P. Oehme
Pathological Physiology and General Pathology


Substance P administered 30 min after the onset of cerebral ischemia improved the neurological status and prevented postischemic hyperactivity in rats with a passive type of behavior; had no effect on the neurological status of rats with an intermediate type of behavior but reduced their postischemic hyperactivity; aggravated the neurological status of rats with an active type of behavior without exerting a significant effect on their behavioral responses; and averted a rise in the level of depression in rats of all three groups. The results of this study indicate that there is a relationship between the type of behavior, manifestations of cerebral ischemia, and the effects of substance P.

Key Words

cerebral ischemia behavioral responses substance P 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • K. Yu. Sarkisova
    • 1
  • I. A. Kolomeitseva
    • 1
  • P. Oehme
    • 2
  1. 1.Group for Experimental Pathology and Therapy of Higher Nervous Activity, Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscow
  2. 2.Institute of Molecular PharmacologyBerlin

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