Inverter mechanism of the influence exerted by insulin on the plasma membranes of cardiac myocytes in rats of different age
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In the plasma membranes of cardiac myocytes from old rats, Na, K-ATPase activity and phosphatidylinositol levels were lower and cardiolipin levels higher than in those from younger (adult) animals. Insulin injected into adult rats elevated Na, K-ATPase activity and phosphatidylethanolarnine levels and caused a sharp fall in phosphatidylinositol levels. In old rats, insulin had no effect on Na, K-ATPase activity, but lowered phosphatidylethanolamine levels. In experiments with cellular hybrids (cytosol+plasma membranes), cytosol from adult rats activated Na, K-ATPase in both adult and old rats, whereas cytosol from old rats failed to activate the enzyme both in old and in adult rats. Actinomycin D prevented the stimulatory effect of insulin on Na,K-ATPase activity.
Key Wordsinsulin myocardium membranes aging
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