Abstract
A histophotometric study of the liver dehydrogenase activity reveals the nature of changes of enzymatic homeostasis and its periodicity in the dynamics of endotoxinemia in dogs. A compensatory reaction to lipopolysaccharide administration develops during the first two hours. A decrease of dehydrogenase and diaphorase activity and the development of structural damage to hepatocytes appear later. It is shown that the activation of free-radical oxidation as well as an increase of the level of medium-sized molecules in the blood plasma play a key role in the pathogenesis of liver damage.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 1, pp. 105–108, January, 1995
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Mishnev, O.D., Ettinger, A.P., Shchegolev, A.I. et al. A quantitative study of dehydrogenase activity of hepatocytes in systemic endotoxinemia. Bull Exp Biol Med 119, 101–104 (1995). https://doi.org/10.1007/BF02445944
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DOI: https://doi.org/10.1007/BF02445944