Abstract
Synthesis and properties of an immunotoxin produced by conjugating ricin with a novel monoclonal antibody (IgG3 of the ICO-104 class) are described. Cytolytic activity of the synthesized immunotoxin, determined by two independent methods and expressed in LD50, is 0.3–0.6×10−7 M. Its specificity for target cells containing the CD5 antigen is shown.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 1, pp. 76–79, January, 1995
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Vikha, G.V., Uzhinova, L.D., Kashaeva, A.Z. et al. Synthesis and properties of the immunotoxin CD5-ricin. Bull Exp Biol Med 119, 70–73 (1995). https://doi.org/10.1007/BF02445936
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DOI: https://doi.org/10.1007/BF02445936