Abstract
Experiments carried out to study thein vitro effects of phosphorylation and dephosphorylation on the activity of the key enzyme of serotonin biosynthesis, tryptophan hydroxylase, from the brain of C57B1 and BALB mice revealed a higher level of endogenous phosphorylation of the enzyme in the brain of BALB mice. The higher maximal activity of the enzyme derived from the brain of C57B1 mice appears to reflect increased expression of tryptophan hydroxylase in the brain of animals of this strain in comparison with BALB. It is possible that interstrain differences in cerebral tryptophan hydroxylase activity are caused mainly by two genetically determined factors: enzyme expression and its reversible phosphorylation.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 1, pp. 67–68, January, 1995
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Kulikov, A.V., Voronova, I.P. Role of reversible phosphorylation in genetically determined polymorphism for cerebral tryptophan hydroxylase. Bull Exp Biol Med 119, 61–63 (1995). https://doi.org/10.1007/BF02445933
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DOI: https://doi.org/10.1007/BF02445933