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Early Resistance to experimental plague in animals immunized with recombinant plague vaccine

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The protective properties of recombinantSalmonella minnesota R595/pFS1 strain soon after immunization (1–3 days) are studied in a model of experimental mouse plague. Unlike the commercial EV strainYersinia pestis vaccine produced at the Saratov Anti-Plague Institute (Mikrob Research-Manufacturing Conglomerate), the experimental recombinant p preparation affords a high level of protection from the 1st day postvaccination, and surpasses the commercial preparation in such parameters as LD50, mean survival time, and percentage of survivors. By the 21st day the protective indexes of both preparations are comparable.

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References

  1. I. P. Ashmarin and A. A. Vorob'ev,Statistical Methods in Microbiological Investigations [in Russian], Leningrad (1962), pp. 85–104.

  2. R. A. Beloborodov, S. M. Dal'vadyants, I. N. Zaitseva, and M. V. Zubova,Probl. Osobo Opasnykh Infektsii, No 3(53), 28–31 (1977).

    Google Scholar 

  3. A. A. Byvalov,Zh. Mikrobiol., No 4, 74–76 (1984).

    PubMed  Google Scholar 

  4. S. M. Dal'vadyants,Characterization of the Somatic Antigens of Plague Microbe Isolated after Bouaven and Westfall-Luderiz [in Russian], PhD Thesis, Saratov (1968).

  5. L. N. Shanina and S. M. Dal'vadyants,Prob. Osobo Opasnykh Infektsii, No 5 (63), 63–64 (1978).

    Google Scholar 

  6. S. N. Chatfield, A. Strugnell, and G. Dougan,Vaccine, 7, No 6, 495–498 (1989).

    Article  PubMed  CAS  Google Scholar 

  7. W. R. McCabe, S. C. Bruins, D. E. Cravon, and M. Johns,J. Immunol.,108, 601–610 (1972).

    PubMed  CAS  Google Scholar 

  8. Potential Use of Live Viral and Bacterial Vectors for Vaccines. WHO,Vaccine,5, 425–437 (1990).

    Google Scholar 

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Authors and Affiliations

  1. State Research Institute of Applied Microbiology, Obolensk, Moscow Region

    T. A. Gremyakova, V. A. Amel'chenko & G. A. Anisimov

Authors
  1. T. A. Gremyakova
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  2. V. A. Amel'chenko
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  3. G. A. Anisimov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny,Vol. 119, No 1, pp. 54–57, January, 1995

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Gremyakova, T.A., Amel'chenko, V.A. & Anisimov, G.A. Early Resistance to experimental plague in animals immunized with recombinant plague vaccine. Bull Exp Biol Med 119, 48–51 (1995). https://doi.org/10.1007/BF02445929

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  • DOI: https://doi.org/10.1007/BF02445929

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