Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 1, pp 43–44 | Cite as

Gastroprotective effect of zinc sulfate in ethanol-induced ulcerogenesis in rats

  • V. A. Trapkov
  • S. D. Gobedzhashvili
  • K. L. Erzinkyan
Pharmacology and Toxicology


In a rat model of ethanol-induced peptic ulcer it is demonstrated that pretreatment with zinc sulfate (intragastral administration) lowers the ethanol-induced damage to the gastral mucosa in a dose-dependent manner. Subcutaneous injection of indomethacin has no appreciable effect on the gastroprotective effect of zinc. It is assumed that the gastroprotective effect of zinc sulfate is not mediated by the release of endogenous prostaglandins.

Key Words

gastroprotective activity zinc sulfate ethanol-induced ulcerogenesis prostaglandins 


  1. 1.
    K. L. Erzinkyan, M. V. Lukasheva, S. D. Gobedzhashvili,et al., Ros. Med. Zh., No 5-12, 14–15 (1992).Google Scholar
  2. 2.
    M. V. Lukasheva, K. L. Erzinkyan, S. D. Gobedzhashvili,et al., in:Evaluation of the Pharmacological Activity of Chemicals: Principles and Approaches [in Russian], Part 2, Moscow (1989), p. 192.Google Scholar
  3. 3.
    P. Bhandre, R. Diniz-D'Souza, A. Mainker, and V. Dhume,Europ. J. Pharmacol.,191, 167–172 (1990).CrossRefGoogle Scholar
  4. 4.
    T. K. Chaudhury and A. Robert,Dig. Dis. Sci.,25, 830–836 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    G. Escolar and O. Bulbena,Drugs Exp. Clin. Res.,15, 83–89 (1989).PubMedGoogle Scholar
  6. 6.
    M. Ito, T. Tanaka, and Y. Suzuzki,Jap. J. Pharmacol.,52, 513–521 (1990).PubMedGoogle Scholar
  7. 7.
    Y. Kurebayashi, Y. Tubuchi, and M. Akasaki,Arzneimittelforschung,39, 250–253 (1989).PubMedGoogle Scholar
  8. 8.
    K. D. Rainsford and M. W. Whitehouse,J. Pharm. Pharmacol.,44, 476–482 (1992).PubMedGoogle Scholar
  9. 9.
    A. Robert, J. E. Nezamis, C. Lancaster,et al., Amer. J. Physiol.,245, G113-G118 (1983).PubMedGoogle Scholar
  10. 10.
    J. L. Wallace, D. R. McCready, B. C. Chin,et al., Clin. Biochem.,17, 179–184 (1984).PubMedCrossRefGoogle Scholar
  11. 11.
    G. Zuccari, G. Clavenna, A. Sala,et al., Europ. J. Pharmacol.,187, 19–25 (1990).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • V. A. Trapkov
    • 1
  • S. D. Gobedzhashvili
    • 1
  • K. L. Erzinkyan
    • 1
  1. 1.Laboratory for the Correction of Metabolic DisordersRussian Scientific Center for the Safety of Biologically Active SubstancesStaraya Kupavna, Moscow Region

Personalised recommendations