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Lowering of lipid peroxidation and acute toxicity of bromobenzene by a polymeric form of zinc-metallothionein

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Plasma and liver contents of malonic aldehyde are studied one day after administration of bromobenzene to mice pretreated with a polymeric form of zinc-metallothionein from rat liver. It is found that zinc-metallothionein injected in a dose of 1–4 mg/kg 5–10 min prior to injection of bromobenzene (2 g/kg, about 56% of LD50) markedly lowers the malonic dialdehyde level and active toxicity of this xenobiotic. Administration of a mixture modeling Zn-metallothionein (albumin, cysteine, and zinc) in a dose of 4 mg/kg has no appreciable effect on the malonic dialdehyde level raised after bromobenzene injection, and does not change its LD50. It is concluded that the protective effect of exogenous zinc-metallothionein is due to its antioxidant activity, which allows for normalization of lipid peroxidation.

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Authors and Affiliations

  1. Institute of Biophysics, Russian Ministry of Health; Institute of Nutrition, Russian Academy of Medical Sciences, Moscow

    A. N. Koterov, M. V. Shagova, N. V. Shilina & I. Ya. Kon'

Authors
  1. A. N. Koterov
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  2. M. V. Shagova
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  3. N. V. Shilina
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  4. I. Ya. Kon'
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 1, pp. 43–45, January, 1995

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Koterov, A.N., Shagova, M.V., Shilina, N.V. et al. Lowering of lipid peroxidation and acute toxicity of bromobenzene by a polymeric form of zinc-metallothionein. Bull Exp Biol Med 119, 37–39 (1995). https://doi.org/10.1007/BF02445925

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  • DOI: https://doi.org/10.1007/BF02445925

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