Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 1, pp 8–11 | Cite as

Effects of neurotropin in pain syndromes

  • G. N. Kryzhanovskii
  • E. I. Danilova
  • V. N. Grafova
  • V. K. Reshetnyak
Pathological Physiology and General Pathology


Neurotropin is shown to hinder the development of a neuropathic pain syndrome induced in rats by sciatic nerve transection and to produce a curative effect in animals that have already developed the pain syndrome. Neurotropin does not prevent the occurrence of adjuvant-induced arthritis in rats but significantly diminishes its manifestations. The observed effects of this agent are attributed to its action on different components of the pathological algetic system.

Key Words

pathological algetic system neuropathic pain syndrome adjuvant arthritis 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • G. N. Kryzhanovskii
    • 1
  • E. I. Danilova
    • 1
  • V. N. Grafova
    • 1
  • V. K. Reshetnyak
    • 1
  1. 1.Laboratory for Pathophysiology of Pain, Research Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow

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