Skip to main content
SpringerLink
Log in

Cascade afteraction of delta sleep-inducing peptide in rats

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Delta sleep-inducing peptide is found to alter markedly the levels of substance P, β-endorphin, and corticosterone in the hypothalamus and blood plasma of rats, suggesting that the long-lasting stress-mitigating effects of this peptide are due to the considerable changes it causes in the content of other oligopeptides and hormones, involving them in various processes. Thus, DSIP itself appears to act only as a trigger, initiating a cascade of interdependent molecular reactions that correlate with the degree of resistance to stress.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. P. Ashmarin,Itogi Nauki i Tekhniki, Seriya Fiziologiya Cheloveka i Zhivotnykh (Recent Advances in Science and Technology) [in Russian], Moscow, Vol. 34, 89–97 (1988).

    Google Scholar 

  2. Yu. V. Polyntsev, E. V. Bykova, E. L. Rogatina, and Yu. N. Samko,Zh. Vyssh. Nervn. Deyat.,41, No 3, 564–572 (1991).

    CAS  Google Scholar 

  3. R. M. Salieva, E. V. Koplik, and Z. A. Kamenov,Byull. Eksp. Biol. Med.,108, No 10, 464–466 (1989).

    CAS  Google Scholar 

  4. R. M. Salieva, K. Yanovskii, R. Ratsak,et al., Zh. Vyssh. Nervn. Deyat.,41, No 3, 558–563 (1991).

    CAS  Google Scholar 

  5. K. V. Sudakov, V. A. Dushkin, and E. A. Yumatov,Vestn. Akad. Med. Nauk SSSR, No 12, 32–39 (1981).

    PubMed  Google Scholar 

  6. K. V. Sudakov, E. V. Koplik, D. F. Vedyaev,et al., Dokl. Akad. Nauk SSSR,267, No 1, 230–233 (1982).

    Google Scholar 

  7. K. V. Sudakov,Pat. Fiziol., No 4, 86–93 (1992).

    Google Scholar 

  8. E. A. Yumatov, in:Central Neurochemical Mechanisms of Resistance to Emotional Stress (doctoral dissertation), Moscow (1986).

  9. M. V. Graf, B. Saegesser, and G. A. Schoenenberger,Peptides,8, 599–603 (1986).

    Article  Google Scholar 

  10. T. P. Khovanskaya and E. V. Koplik,Neuroscience,15, 11–19 (1989).

    CAS  Google Scholar 

  11. A. Lopez-Calderon, C. Ariznavarreta, and C. Chen,J. Endocrinol.,124, No 2, 241–246 (1991).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Physiology of Emotions and Emotional Stress and Laboratory for Physiology of Motivations, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow

    K. V. Sudakov, A. V. Kotov, R. M. Salieva, Yu. V. Polyntsev & E. V. Koplik

  2. Howard Florey Institute of Experimental Physiology and Medicine, Australia

    J. P. Coghland

Authors
  1. K. V. Sudakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. P. Coghland
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Kotov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. M. Salieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. V. Polyntsev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. V. Koplik
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 1, pp. 6–9, January, 1995

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sudakov, K.V., Coghland, J.P., Kotov, A.V. et al. Cascade afteraction of delta sleep-inducing peptide in rats. Bull Exp Biol Med 119, 1–4 (1995). https://doi.org/10.1007/BF02445915

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445915

Key Words

Search

Navigation