Abstract
A hypothesis about a correlation between threshold pain sensitivity and antibody production is proposed and experimentally validated. Immunodeficient mouse strains are characterized by a higher threshold sensitivity to pain than animals with a normal immune response. A highly reliable negative correlation between threshold sensitivity to pain assessed by the hot plate test and the number of antibody-producing cells in the spleen after immunization with sheep red cells is observed in 77% of (CBA×C57B1/6) F1 mice examined. The negative correlation is observed both in spontaneous variations of threshold pain sensitivity and during an elevation of this threshold under the effect of preceding nociceptive stimulation.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 405–408, April, 1995
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Vasilenko, A.M., Yanovskii, O.G., Koptelov, O.V. et al. Correlation of pain sensitivity and the humoral immune response in mice during thermal stimulation. Bull Exp Biol Med 119, 393–396 (1995). https://doi.org/10.1007/BF02445902
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DOI: https://doi.org/10.1007/BF02445902