Abstract
Specific features of immune-endocrine interrelationships and of pituitary-adrenal system functioning are studied in NZB mice with hereditary autoimmune pathology. It is established that the development of disease is accompanied by a weakened response to stress, reduced blood corticosteroid level, and decreased adrenal reactivity to exogenous adrenocorticotropic hormone. Moreover, a loss of sensitivity to interleukin-2 is observed. These facts provide evidence of disturbed interaction between the immune and endocrine systems as well as of inhibition of pituitary-adrenal system activity as the autoimmune disease develops.
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References
Mechanisms of Seasonal Rhythms of Corticosteroid Regulation in Hibernating Animals [in Russian], Ed. M. G. Kolpakov, Novosibirsk (1978).
E. V. Naumenko and N. N. Dygalo,Ontogenez,10, No 5, 476–482 (1979).
A. A. Tinnikov and N. M. Bazhan,Lab. Delo, No 12, 709–713 (1984).
H. O. Besedovsky, A. Del Rey, and E. Sorkin,Immunoregulation, Eds. N. Fabriset al., new York — London (1983), pp. 315–339.
J. C. Cambronero, F. J. Rivas, J. Borrell, and C. Guaza,J. Endocr.,131, No 2, 667–683 (1992).
G. R. Crabtree, S. Gillis, K. A. Smith, and A. Munck,J. Steroid Biochem.,12, 445–449 (1980).
M. J. Justice, N. A. Jenkins, and N. G. Copeland,Tibtech.,10, 120–126 (1992).
S. Karanth and S. M. McCann,Proc. Nat. Acad. Sci. USA,88, 2961–2965 (1991).
G. Kroemer and G. Wick,Immunol. Today,10, No 7, 246–251 (1989).
G. Long, M. C. Holmes, and Z. M. Burnet,Aust. J. Exp. Biol. Med. Sci.,41, 315–321 (1963).
K. L. Shauenstein, R. Fassler, H. Dietrich,et al., J. Immunol.,139, No 6, 1830–1833 (1987).
S. Sierakowsky and J. C. Goodwin,Clin. Exp. Immunol.,71, 198–201 (1988).
N. L. Warner,Autoimmuning, Ed. N. Talal (1977), pp. 33–62.
P. Zelanowsky, M. A. Smith, P. W. Gold,et al., Neuroendocrinology,56, 474–482 (1992).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 394–397, April, 1995
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Chesnokova, V.M., Ivanova, A.N., Karyagina, A.Y. et al. Patterns of interaction between the immune and endocrine systems in the manifestation of hereditary autoimmune disorders in NZB mice. Bull Exp Biol Med 119, 381–384 (1995). https://doi.org/10.1007/BF02445899
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DOI: https://doi.org/10.1007/BF02445899