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Effect of oxipine on the severity of anaphylactic shock and the ratio of lipid fractions in lymphocytes of allergic rabbits

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that oxipine (mexidol; a 3-hydroxypyridine-derived antioxidant) injected intravenously into rabbits in a dose of 10 or 25 mg/kg alleviates the severity of the anaphylactic reaction, lowers the anaphylactic index, and considerably reduces the percentage of anaphylaxic shock-induced mortality. The preparation causes changes in the ratio of the total lipid to phospholipid fractions of lymphocytes, which has distinctive features in intact, primed, and challenged animals. It is thought that the antiallergic effects of oxipine are connected with both inhibition of free-radical oxidation and with the ability of the preparation to alter receptor properties of the allergy target cells due to its effect on the lipid ensembles of the cell membranes.

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Authors and Affiliations

  1. Department of Pharmacology with a Course in Clinical Pharmacology, Tver' Medical Institute, Staraya Kupavna, Moscow Region

    G. A. Bazanov & L. D. Smirnov

  2. All-Russian Research Center for the Safety of Biologically Active Substances, Staraya Kupavna, Moscow Region

    G. A. Bazanov & L. D. Smirnov

Authors
  1. G. A. Bazanov
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  2. L. D. Smirnov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 384–386, April, 1995

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Bazanov, G.A., Smirnov, L.D. Effect of oxipine on the severity of anaphylactic shock and the ratio of lipid fractions in lymphocytes of allergic rabbits. Bull Exp Biol Med 119, 371–373 (1995). https://doi.org/10.1007/BF02445896

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  • DOI: https://doi.org/10.1007/BF02445896

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