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Toxic effect of glutamate causes mitochondria damage in granule cells of dissociated cultures of rat cerebellum

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that treating rat cerebellum with glutamate in a neurocytotoxic concentration causes a drop of the mitochondrial membrane potential in granule cells and leads to ultrastructural alterations of mitochondria in these neurons.

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 378–380, April, 1995.

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Isaev, N.K., Uzbekov, R.E., Zorov, D.B. et al. Toxic effect of glutamate causes mitochondria damage in granule cells of dissociated cultures of rat cerebellum. Bull Exp Biol Med 119, 365–367 (1995). https://doi.org/10.1007/BF02445894

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  • DOI: https://doi.org/10.1007/BF02445894

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