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Antiarrhythmic properties of Dimebon

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The H1-receptor blocker Dimebon is shown to exhibit pronounced antiarrhythmic properties. Its activity and therapeutic action range (toxic/therapeutic ratio) exceed those of quinidine, ethmosine, isoptin, and bonnecor in several animal models of cardiac arrhythmia. The mechanism of its antiarrhythmic action is probably associated with blockade of sodium and particularly calcium channels, prolongation of the effective refractory period, and slowing of impulse traffic in the conduction system of the heart. Dimebon may be recommended for submission to clinical trials as an antiarrhythmic agent.

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Authors and Affiliations

  1. Department of Pharmacology, Kuban Medical Institute, Krasnodar

    P. A. Galenko-Yaroshevskii, O. A. Chekanova, V. V. Skibitskii, V. V. Bartashevich, A. I. Khankoeva & T. I. Polyashova

Authors
  1. P. A. Galenko-Yaroshevskii
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  2. O. A. Chekanova
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  3. V. V. Skibitskii
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  4. V. V. Bartashevich
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  5. A. I. Khankoeva
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  6. T. I. Polyashova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 375–377, April, 1995

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Galenko-Yaroshevskii, P.A., Chekanova, O.A., Skibitskii, V.V. et al. Antiarrhythmic properties of Dimebon. Bull Exp Biol Med 119, 362–364 (1995). https://doi.org/10.1007/BF02445893

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  • DOI: https://doi.org/10.1007/BF02445893

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