Abstract
It is shown that during stress a rapid twofold increase of erythrocyte acid resistance in rats of both sexes was followed by a 1.5-fold decrease toward the 60th min in males and the 120th min in females. In males, in contrast to females, the level of malonic dialdehyde was raised not only during stress, but also 1 and 24 hours after its completion. Stress-induced dystrophic changes of cardiomyocytes were more marked in males. The area of myocardial damage in females was almost twice as small as in males. It is assumed that the better resistance of females to stress-induced cardiovascular damage may be due to increased efficacy of antioxidant mechanisms inhibiting lipid peroxidation.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 354–357, April, 1995
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Anishchenko, T.G., Brill, G.E., Romanova, T.P. et al. Sex-related differences in the degree of lipid peroxidation activation and resistance to cardiovascular damage induced by stress in rats. Bull Exp Biol Med 119, 340–343 (1995). https://doi.org/10.1007/BF02445887
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DOI: https://doi.org/10.1007/BF02445887