Abstract
In experiments on rabbits under Nembutal anesthesia, intravenous injection of flunitrazepam in a single dose of 0.125 mg/kg in combination with delta sleep-inducing peptide in a single dose of 60 nmol/kg raised the threshold of ventricular fibrillation to a level that was significantly higher than that after injection of flunitrazepam alone in the same dose and comparable to that after injection of this benzodiazepine alone in twice as high a dose (0.25 mg/kg), but without the side effects (persistent hypotension and transient bradycardia) produced by the latter dose. It is concluded that the ability of jointly acting delta sleep-inducing peptide and flunitrazepam to increase the electrical stability of the heart may have practical relevance to the prevention of ventricular arrhythmias occurring under conditions of emotional stress and myocardial ischemia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. I. Arkhangel'skaya and M. A. Zvyagintseva,Pat. Fiziol., No 2, 45–49 (1989).
F. Z. Meerson,Kardiologiya,33, No 4, 50–59 (1993).
A. M. Mendzheritskii, M. G. Makletsova, and I. Yu. Karpukhina,Neirokhimiya,6, No 3, 422–428 (1987).
K. V. Sudakov,Fiziol. Zh., No 3, 1–13 (1991).
L. S. Ul'yaninskii,Fiziol. Zh., No 10, 1273–1279 (1990).
L. S. Ul'yaninskii, M. I. Arkhangel'skaya, M. A. Zvyagintseva,et al., Trudy Nauchnogo soveta po eksperimental'noi i prikladnoi fiziologii RAMN [Transactions of the Scientific Council for Experimental and Applied Physiology at the Russian Academy of Medical Sciences], Vol. 1, Moscow (1992), pp. 86–102.
G. G. Chichkanov,Farmakol. Toksikol., No 3, 303–307 (1975).
J. A. Di Micco and V. M. Abshire,Brain Res.,402, 1–10 (1987).
J. Han,Amer. J. Cardiol.,7, 1165–1187 (1969).
M. A. K. Mattila and H. M. Larni,Drugs,20, 353–374 (1980).
M. K. Poddar, D. A. Urquhart, and A. K. Sinha,Brain Res. Bull.,5, Suppl. 2, 279–284 (1980).
J. E. Skinner, in:Stress and Heart Disease, ed. R. E. Beamish, Boston (1985), pp. 44–59.
J. E. Tallman and D. Gallager,Ann. Rev. Neurosci.,8, 21–44 (1985).
M. Vrana, L. Hess, Z. Vranova,et al., Czech. Med.,10, No 3, 142–155 (1987).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 342–345, April, 1995
Rights and permissions
About this article
Cite this article
Arkhangel'skaya, M.I., Drahotova, D. Delta sleep-inducing peptide and flunitrazepam acting jointly increase cardiac electrical stability. Bull Exp Biol Med 119, 329–332 (1995). https://doi.org/10.1007/BF02445884
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02445884