Induction of cytotoxic T lymphocytes specific to the molecule of the class I major histocompatibility complex for subcutaneous immunization in pads

Abstract

T lymphocytes from immune lymph nodes, specific to the molecule of the class I major histocompatibility complex, were found to contain cytotoxic T lymphocyte precursors which mature to become effector cytotoxic T lymphocytes only in the presence of helper cells and L3T4⁺, but not Lyt2⁺ T helpers. The findings indicate that a subcutaneous injection of alloantigen of the class I major histocompatibility complex for immunization in the pads leads to the creaction of the type of microenvironment of the lymph nodes which prevents activation of Lyt2⁺ T helpers or leads to the activation of their functionally negligible part.