Delta sleep-inducing peptide is shown to alter properties of malate dehydrogenase in brain mitochondria. The regulatory activity of the peptide is manifested in stabilization of catalytic properties of the enzyme at a higher level, which prevents their change during hypoxic stress. Regulation of malate dehydrogenase is presumed to occur through direct action of the peptide on mitochondrial membranes.
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Translated fromByulleten Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 2, pp. 141–143, February, 1995
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Khvatova, E.M., Gainullin, M.R. & Mikhaleva, I.I. Effect of delta sleep-inducing peptide on catalytic properties of mitochondrial malate dehydrogenase from rat brain. Bull Exp Biol Med 119, 132–134 (1995). https://doi.org/10.1007/BF02445857