Abstract
Delta sleep-inducing peptide is shown to alter properties of malate dehydrogenase in brain mitochondria. The regulatory activity of the peptide is manifested in stabilization of catalytic properties of the enzyme at a higher level, which prevents their change during hypoxic stress. Regulation of malate dehydrogenase is presumed to occur through direct action of the peptide on mitochondrial membranes.
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References
I. P. Ashmarin,Vopr. Med. Khimii, No 2, 2 (1984).
A. Cornish-Bowden,Fundaments of Enzyme Kinetics, Butterworth (1979).
B. I. Kurganov,Allosteric Enzymes [in Russian], Moscow (1978).
A. M. Mendzheritskii, M. G. Makletsova, N. I. Uskova,et al., Ukr. Biokhim. Zh., No 1, 34 (1991).
V. V. Rozhanets, R. Yu. Yukhananov, M. A. Chizhevskaya, and E. V. Navolotskaya,Neirokhimiya, No 4, 353 (1983).
K. V. Sudakov,Fiziol. Zh. SSSR, No 3, 1 (1991).
E. M. Khvatova and A. Garcia,Neirokhimiya, No 2, 225 (1988).
E. M. Khvatova, A. Garcia, Yu. V. Zimin, and T. S. Semenova,, No 1, 39 (1989).
E. M. Khvatova, E. L. Dovedova, and I. I. Mikhaleva,Neirokhimiya, No 1, 57 (1987).
G. L. Atkins and J. A. Nimmo,Analyt. Biochem.,104, 1 (1980).
A. Fonyo and I. Somogyi,Acta Physiol. Acad. Sci. Hung., No 3, 191 (1960).
M. V. Graf and A. J. Kastin,Peptides, No 7, 1165 (1986).
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Translated fromByulleten Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 2, pp. 141–143, February, 1995
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Khvatova, E.M., Gainullin, M.R. & Mikhaleva, I.I. Effect of delta sleep-inducing peptide on catalytic properties of mitochondrial malate dehydrogenase from rat brain. Bull Exp Biol Med 119, 132–134 (1995). https://doi.org/10.1007/BF02445857
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DOI: https://doi.org/10.1007/BF02445857