Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 2, pp 132–134 | Cite as

Effect of delta sleep-inducing peptide on catalytic properties of mitochondrial malate dehydrogenase from rat brain

  • E. M. Khvatova
  • M. R. Gainullin
  • I. I. Mikhaleva
Biophysics and Biochemistry


Delta sleep-inducing peptide is shown to alter properties of malate dehydrogenase in brain mitochondria. The regulatory activity of the peptide is manifested in stabilization of catalytic properties of the enzyme at a higher level, which prevents their change during hypoxic stress. Regulation of malate dehydrogenase is presumed to occur through direct action of the peptide on mitochondrial membranes.

Key Words

NAD-dependent malate dehydrogenase delta sleep-inducing peptide hypoxic stress mitochondria brain 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • E. M. Khvatova
    • 1
    • 2
  • M. R. Gainullin
    • 1
    • 2
  • I. I. Mikhaleva
    • 1
    • 2
  1. 1.Department of BiochemistryMedical InstituteNizhnii Novgorod
  2. 2.Shemyakin Institute of Bioorganic ChemistryRussian Academy of SciencesMoscow

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