Neurotropic effects of a luliberin analog administered intraventricularly to rats with different sensitivities to ethanol
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In experiments with random-bred male rats separated into short and long sleepers according to the duration of ethanol-induced sleep (narcosis), a synthetic luliberin analog (Surfagon) administered into a brain ventricle was found to reduce pain sensitivity and affective aggressiveness in response to unavoidable painful electrostimulation, and to increase convulsive activity. Short-sleeping rats differed from long-sleeping ones in showing greater behavioral excitability and aggressiveness and in being more responsive to Surfagon, which lowered both these parameters in the former rats to a greater extent than in the latter before castration as well as after it. Mechanisms of the observed behavioral effects of Surfagon are discussed, and it is concluded that they are not mediated by sex steroids, and that the major factor in the mechanisms of its action is the accessibility of limbic structures and of the central gray substance in the midbrain.
Key Wordsluliberin Surfagon stress aggressive/defensive behavior alcohol motivation
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