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Immune response to the terminal repeat protein of epstein-barr virus in patients with undifferentiated nasopharyngeal carcinoma

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Screening of 205 patients suffering from various diseases and healthy donors for the presence of serum antibodies to terminal repeat protein (TP) of Epstein-Barr virus was carried out using the indirect immunofluorescence technique. TP antibodies were detected exclusively in patients with undifferentiated nasopharyngeal carcinoma (in 30–40% of patients within this group). Evaluation of TP antibody titers before and after treatment revealed a correlation between the dynamics of these antibodies and the clinical prognosis of patients.

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Authors and Affiliations

  1. Laboratory of Viral Cancinogenesis, Research Institute of Carcinogenesis, Russian Academy of Medical Sciences, Moscow

    T. A. Afanas'eva, N. V. Belousova, T. T. Kondrat'eva, N. A. Probatova, V. N. Stepina, N. A. Mikhailova, O. A. Pavlish, L. N. Shcherbak, B. M. Aliev, V. S. Alferov & V. E. Gurtsevich

  2. Institute of Clinical Oncology, Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    T. A. Afanas'eva, N. V. Belousova, T. T. Kondrat'eva, N. A. Probatova, V. N. Stepina, N. A. Mikhailova, O. A. Pavlish, L. N. Shcherbak, B. M. Aliev, V. S. Alferov & V. E. Gurtsevich

Authors
  1. T. A. Afanas'eva
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  2. N. V. Belousova
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  3. T. T. Kondrat'eva
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  4. N. A. Probatova
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  5. V. N. Stepina
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  6. N. A. Mikhailova
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  7. O. A. Pavlish
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  8. L. N. Shcherbak
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  9. B. M. Aliev
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  10. V. S. Alferov
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  11. V. E. Gurtsevich
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 3, pp. 311–314, March, 1995

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Afanas'eva, T.A., Belousova, N.V., Kondrat'eva, T.T. et al. Immune response to the terminal repeat protein of epstein-barr virus in patients with undifferentiated nasopharyngeal carcinoma. Bull Exp Biol Med 119, 303–306 (1995). https://doi.org/10.1007/BF02445843

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  • DOI: https://doi.org/10.1007/BF02445843

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