Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 3, pp 291–293 | Cite as

Comparison of the neurotropic and stress-protecting properties of piracetam and pyrido[1,2-a]pyrimidine derivative

  • M. M. Kozlovskaya
  • A. N. Inozemtsev
  • S. V. Nikitin
  • A. G. Gochmuradov
  • R. A. Yakushev
  • R. Chabak-Gorbach
Pharmacology and Toxicology

Abstract

A new pyrido[1,2-a]pyrimidine derivative causes psychostimulation in albino rats expressed in accelerated learning during the elaboration of the avoidance reaction in a shuttle box. It is also shown that on a model of acute emotional stress induced by a disturbance of the unambiguity of cause-effect relationships in the experimental setting this compound exhibits a stress-protecting effect which is comparable to the effect of piracetam.

Key Words

stress nootropics antidepressants psychostimulators pyridopyrimidines 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. N. Inozemtsev,Biol. Nauki, No 4, 47–53 (1985).PubMedGoogle Scholar
  2. 2.
    A. N. Inozemtsev,Vest. Mosk. Univ., Ser. Biologiya, No 4, 60–66 (1988).Google Scholar
  3. 3.
    A. N. Inozemtsev, in:Comparative Physiology of Human and Animal Higher Nervous Activity [in Russian], Moscow (1990), pp. 36–58.Google Scholar
  4. 4.
    A. N. Inozemtsev and L. L. Pragina,Zh. Vyssh. Nerv. Deyat.,39, No 4, 764–766 (1989).Google Scholar
  5. 5.
    A. N. Inozemtsev, F. F. Kokaeva, I. I. Kozlovskii,et al., Byull. Eksp. Biol. Med.,109, No 5, 445–446 (1990).CrossRefGoogle Scholar
  6. 6.
    E. G. Petukhova and M. M. Kozlovskaya,Zh. Vyssh. Nerv. Deyat.,41, No 4, 708–716 (1991).Google Scholar
  7. 7.
    L. L. Pragina, T. A. Voronina, A. N. Inozemtsev,et al., Farmakol. Toksikol.,53, No 5, 8–10 (1990).PubMedGoogle Scholar
  8. 8.
    P. V. Simonov,The Emotional Brain [in Russian], Moscow (1981).Google Scholar
  9. 9.
    A. N. Inozemtsev,Acta Cient. Venez.,34, No 2, 159–167 (1983).Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • M. M. Kozlovskaya
    • 1
    • 2
  • A. N. Inozemtsev
    • 1
    • 2
  • S. V. Nikitin
    • 1
    • 2
  • A. G. Gochmuradov
    • 1
    • 2
  • R. A. Yakushev
    • 1
    • 2
  • R. Chabak-Gorbach
    • 1
    • 2
  1. 1.Laboratory of Pharmacogenetics, Research Institute of PharmacologyRussian Academy of Medical SciencesMoscow
  2. 2.Laboratory of Evolution of Memory Mechanisms, Department of BiologyLomonosov State UniversityMoscow

Personalised recommendations