Abstract
The effect of the purine receptor ligands N-ethylcarboxamide adenine and adenosine and of the purine antagonists mercaptopurine and azathioprine on the intracellular cAMP content in human peripheral blood lymphocytes and bone marrow lymphoblasts was studied. All preparations tested induced an increase in the cAMP level in peripheral blood lymphocytes. The selective immunosuppressive effect of adenosine antagonists may be due to their ability to modulate the activity of adenylate cyclase in lymphoid cells.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 3, pp. 294–296, March, 1995
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Dukhanin, A.S., Sergeev, P.V., Stankevich, L.I. et al. Effect of purine antagonists on the cAMP level in lymphocytes and bone marrow lymphoblasts. Bull Exp Biol Med 119, 285–287 (1995). https://doi.org/10.1007/BF02445837
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DOI: https://doi.org/10.1007/BF02445837