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Increased resistance to heat shock of isolated hearts from rats adapted to moderate physical exercise

  • Pathological Physiology and General Pathology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Hearts isolated from rats adapted to physical activity through moderate regular exercise (swimming) were more resistant to heat shock than hearts from unadapted controls. Thus, 15-min perfusion of control hearts with a solution heated to 42°C significantly depressed contraction amplitudes and caused a contracture amounting to 36% of the initial contraction amplitude, as well as increased release of creatine kinase into the perfusate. In the hearts from adapted rats, contraction amplitude was, on average, 2.3-fold greater and the contracture 3.2 times less marked than in the control animals; the test and control hearts did not differ significantly in the release of creatine kinase.

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Authors and Affiliations

  1. Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow

    I. Yu. Malyshev, P. A. Prodius & F. Z. Meerson

Authors
  1. I. Yu. Malyshev
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  2. P. A. Prodius
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  3. F. Z. Meerson
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 3, pp. 256–258, March, 1995

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Malyshev, I.Y., Prodius, P.A. & Meerson, F.Z. Increased resistance to heat shock of isolated hearts from rats adapted to moderate physical exercise. Bull Exp Biol Med 119, 245–247 (1995). https://doi.org/10.1007/BF02445826

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  • DOI: https://doi.org/10.1007/BF02445826

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