Bulletin of Experimental Biology and Medicine

, Volume 119, Issue 3, pp 219–224 | Cite as

A soluble form of guanylate cyclase in the molecular mechanism of the physiological effects of nitrogen oxide and in the regulation of platelet aggregation

  • I. S. Severina


The articles is devoted to the role of heme in soluble guanylate cyclase functioning, the molecular mechanism of nitrogen oxide activation of guanylate cyclase, the role of guanylate cyclase in the process of platelet aggregation, and the mechanism of the antihypertensive and antiaggregative action of certain activators of the enzyme.

Key Words

guanylate cyclase heme nitrogen oxide human platelets aggregation 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • I. S. Severina
    • 1
    • 2
  1. 1.Department of Physiologically Active Peptides, Institute of Biomedical ChemistryRussian Academy of Medical Sciences, MoscowMoscowRussia
  2. 2.Guanylate Cyclase System, Institute of Biomedical ChemistryRussian Academy of Medical Sciences, MoscowMoscowRussian

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