Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 3, pp 1030–1032 | Cite as

Effect of experimental hyperprolactinemia on the sexual cycle and folliculogenesis

  • T. G. Borovaya
  • O. V. Volkova
Morphology and Pathomorphology


It is found that hyperprolactinemia results in the development of stable anovulation, in which the disruption of folliculogenesis sets in as early as at the stage of late preantral (graafian) follicles and manifests itself in a decrease of the mitotic activity in cells of the membrana granulosa. The concentration of follicle-stimulating hormone thereupon changes to different extents or remains at the control level. A direct influence of prolactin on intrafollicular estrogen production and on cell division is postulated.

Key Words

ovary follicle prolactin anovulation 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • T. G. Borovaya
    • 1
  • O. V. Volkova
    • 1
  1. 1.Department of Histology and Embryology, Pediatric FacultyRussian State Medical UniversityMoscow

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