Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 3, pp 962–965 | Cite as

Role of estrogens in the regulation of prolactin receptors in liver cells of female rats

  • O. M. Petrashchuk
  • O. V. Smirnova
  • A. N. Smirnov
Biophysics and Biochemistry


Strong expression of prolactin receptors in sinusoidal domains and cytoplasmic granules of hepatocytes, which is independent of cell location in the hepatic lobule and is positively regulated by estrogens, is revealed in pubertal female rats. In estrogen-treated animals, Prolactin receptors are also exposed in the perinuclear space of some hepatocytes surrounding the central veins. Estrogens regulate the intensity of prolactin receptors expression in hepatocytes, but not the number of cells containing these receptors.

Key Words

immunohistochemistry prolactin receptors rat liver estrogens 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • O. M. Petrashchuk
    • 1
  • O. V. Smirnova
    • 1
  • A. N. Smirnov
    • 1
  1. 1.Laboratory of Endocrinology, Biology DepartmentM. V. Lomonosov State UniversityMoscow

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