Bulletin of Experimental Biology and Medicine

, Volume 118, Issue 6, pp 1273–1275 | Cite as

Opiatergic mechanisms of the cardiotropic effect of acute cooling

  • S. A. Afanas'ev
  • E. D. Alekseeva
  • Yu. B. Lishmanov
Pathological Physiology and General Pathology


Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for each animal in chambers at −10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components, and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate receptors.

Key Words

cold exposure isolated heart contractility 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • S. A. Afanas'ev
    • 1
  • E. D. Alekseeva
    • 1
  • Yu. B. Lishmanov
    • 1
  1. 1.Department of Experimental Cardiology, Research Institute of Cardiology, Tomsk Research CenterRussian Academy of Medical SciencesTomskUSSR

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