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Correction of hyperlipoproteinogenic microangiopathy and organ pathology with thymalin and leu-enkephalin in the early stages of atherogenesis

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of thymalin and leu-enkephalin on lipid peroxidation and microcirculatory disorders in the early stages of atherogenesis are compared. Correction of the generalized microcirculatory response to hyperlipoproteinemia with the peptides manifested itself in the regression of atherosclerotic lesions in the aorta and restoration of the morphofunctional state of the myocardium and liver.

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References

  1. G. A. Vilkov, E. M. Stepanenko, and G. N. Kryzhanovskii,Byull. Eksp. Biol. Med.,104, No 9, 288 (1987).

    CAS  Google Scholar 

  2. A. S. Gavrish,Arkh. Pat., No 5, 11 (1990).

    Google Scholar 

  3. E. D. Klimenko, A. K. Kranchev, and O. M. Pozdnyakov,Byull. Eksp. Biol. Med.,92, No 11, 530 (1981).

    CAS  Google Scholar 

  4. E. D. Klimenko and O. M. Pozdnyakov, —Ibid.,114, No 10, 437 (1992).

    CAS  Google Scholar 

  5. E. D. Klimenko,Hyperlipoproteinogenic Microangiopathy in the Genesis of Organ Pathology and Pathogenetic Approaches to its Correction, Doctoral Dissertation [in Russian], Moscow (1994).

  6. A. N. Klimov, V. A. Nagornov, and Yu. N. Zubzhitskii,Kardiologiya, No 12, 22 (1982).

    Google Scholar 

  7. E. Ya. Nasonov and V. A. Vinogradov,Byull. Vsesoyuzn., Kardiol. Nauch. Tsentra, No 1, 3 (1987).

    Google Scholar 

  8. O. M. Pozdnyakov and E. D. Klimenko,Vestn. Akad. Med. Nauk SSSR, No 2, 35 (1988).

    Google Scholar 

  9. O. M. Pozdnyakov, E. D. Klimenko, L. P. Kobozeva,et al., Byull. Eksp. Biol. Med.,115, No 3, 242 (1993).

    Article  Google Scholar 

  10. V. D. Slepushkin, Yu. B. Lishmanov, G. K. Zoloev,et al., Usp. Fiziol. Nauk, No 4, 106 (1985).

    Google Scholar 

  11. V. Kh. Khavinson,Vopr. Med. Khimiii, No 3, 41 (1990).

    Google Scholar 

  12. V. K. Khugaeva, P. N. Aleksandrov, E. D. Klimenko,et al., Byull. Eksp. Biol. Med.,100, No 7, 15 (1985).

    CAS  Google Scholar 

  13. V. K. Khugaeva,Fiziol. Zh. SSSR,76, No 1, 92–99 (1990).

    PubMed  CAS  Google Scholar 

  14. F. Bloom and I. Herd, in:Behaviour and Arteriosclerosis, New York (1983), p. 33.

  15. O. M. Pozdnyakov and E. D. Klimenko,Microcirculatory Studies: Clinical and Experimental, Linkoping (1991), p. 3.

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Authors and Affiliations

  1. Laboratory of Experimental Pathomorphology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    O. M. Pozdnyakov, E. D. Klimenko, L. P. Kobozeva, A. B. Michunskaya & I. Yu. Khabarina

Authors
  1. O. M. Pozdnyakov
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  2. E. D. Klimenko
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  3. L. P. Kobozeva
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  4. A. B. Michunskaya
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  5. I. Yu. Khabarina
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 1, pp. 108–111, January, 1996

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Pozdnyakov, O.M., Klimenko, E.D., Kobozeva, L.P. et al. Correction of hyperlipoproteinogenic microangiopathy and organ pathology with thymalin and leu-enkephalin in the early stages of atherogenesis. Bull Exp Biol Med 121, 100–103 (1996). https://doi.org/10.1007/BF02445719

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  • DOI: https://doi.org/10.1007/BF02445719

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