Bulletin of Experimental Biology and Medicine

, Volume 121, Issue 1, pp 81–82 | Cite as

Comparative study of metastases of human melanoma strain Mel-7 in nude and beige/nude mice

  • I. P. Bryzgalov
  • Yu. D. Sorokina
  • Yu. N. Solov'ev
  • E. S. Revazova
Oncology

Abstract

Metastases to the lungs after subcutaneous transplantation of human melanoma Mel-7 to nude and beige/nude mice are situated deep inside the organ closer to the root. Despite a larger size of xenograft in nude mice, the metastasizing process was more expressed in beige/nude mice with a more severe immunodeficiency, which was reflected in an increased number of metastases and their greater total volume in the lungs.

Key Words

metastases xenograft nude mice 

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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • I. P. Bryzgalov
    • 1
  • Yu. D. Sorokina
    • 1
  • Yu. N. Solov'ev
    • 1
  • E. S. Revazova
    • 1
  1. 1.Cancer Research CenterRussian Academy of Medical SciencesMoscow

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