Abstract
Destructive changes and disturbances of spermatogenesis are found to occur in the testes of Wistar rats 1 and 3 months after a single injection of the anthracycline antibiotic pharmorubicin in the maximum permissible dose. The morphological picture normalizes 6 months postinjection. Disturbances in reproductive function are observed as early as 3 months after treatment. The number of dominant lethal mutations rises one month postinjection.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. M. Belen'kii, in:Quantifying Pharmacological Effects [in Russian], Leningrad (1963), pp. 81–106.
T. G. Borovskaya, M. V. Filippova, M. G. Skorokhodova,et al., in: Current Topics in Pharmacology and in the Search for New Drugs [in Russian], Vol. 7, Tomsk (1994), pp. 84–85.
M. M. Vyadro and T. G. Terent'eva,Antibiotiki, No 5, 370–379 (1988).
A. M. Garin,Vopr. Onkol.,29, No 1, 93–98 (1983).
E. D. Gol'dberg, T. G. Borovskaya, T. I. Fomina,et al., Byull. Eksp. Biol. Med.,119, No 3, 305–310 (1995).
E. D. Gol'dberg and V. V. Novitskii,Cancer-Fighting Antibiotics and the Blood System [in Russian], Tomsk (1986).
I. V. Sanotskii and V. N. Fomenko,Delayed Effects of Chemical Compounds on the Organism [in Russian], Moscow (1979).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 1, pp. 55–58, January, 1996
Rights and permissions
About this article
Cite this article
Gol'dberg, E.D., Borovskaya, T.G., Fornina, T.I. et al. Delayed damaging effects of anthracycline antibiotics on the reproductive system of rats. Bull Exp Biol Med 121, 50–52 (1996). https://doi.org/10.1007/BF02445705
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02445705