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Effect of amiridine and tacrine on the functional degeneration of the isolated neuron

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Amiridine and tacrine are found to have a concentration-dependent effect on the spontaneous activity of an isolated neuron from crawfish. Amiridine in a concentration of 1 μM reliably prolongs the lifetime of the neuron, whereas lower concentrations are inactive and a high concentration (10 μM) reduces spontaneous activity. Tacrine is unable to prolong the lifetime of the neuron. It is suggested that, unlike tacrine, the therapeutic effect of amiridine stems from its ability to prolong neuronal functioning.

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Authors and Affiliations

  1. Russian Research Center for the Safety of Bioactive Compounds, Rostov-on-Don, USSR

    Yu. V. Burov & T. N. Robakidze

  2. Institute of Neurocybernetics, Rostov-on-Don University, Rostov-on-Don, USSR

    A. B. Uzdenskii

Authors
  1. Yu. V. Burov
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  2. A. B. Uzdenskii
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  3. T. N. Robakidze
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 1, pp. 52–54, January, 1996

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Burov, Y.V., Uzdenskii, A.B. & Robakidze, T.N. Effect of amiridine and tacrine on the functional degeneration of the isolated neuron. Bull Exp Biol Med 121, 48–50 (1996). https://doi.org/10.1007/BF02445704

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  • DOI: https://doi.org/10.1007/BF02445704

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