Skip to main content
SpringerLink
Log in

On the involvement of endogenous μ- and δ-opiate receptor agonists in the antiarrhythmic effect of adaptation

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Rats adapted to stress showed a decreased severity and incidence of cardiac arrhythmias induced by epinephrine, and these effects of adaptation were abolished by naloxone. It is suggested that stress adaptation mitigates arrhythmia by activating the endogenous opioid system and stimulating the μ-opiate receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yu. N. Kopylov,Role of Regulatory Molecular Mechanisms in the Adaptive Protection of the Heart [in Russian] Synopsis of Doctoral Dissertation, Moscow (1992).

  2. F. Z. Meerson and I. Yu. Malyshev,The Phenomenon of Adaptive Stabilization of Structures, and Protection of the Heart [in Russian], Moscow (1993).

  3. Yu. B. Lishmanov and L. N. Maslov,Opioid Neuropeptides, Stress, and Adaptive Protection of the Heart [in Russian], Tomsk (1994).

  4. M. Broccardo and G. Improta,Eur. J. Pharmacol.,218, 69–73 (1992).

    Article  PubMed  CAS  Google Scholar 

  5. Y. Kohama, K. Iwabuchi, T. Shibahara, and M. Okabe,J. Pharmacobiodyn.,9, 806–810 (1986).

    PubMed  CAS  Google Scholar 

  6. J. J. Lynch, R. G. Rahwan, and D. T. Witiak,J. Cardiovasc. Pharmacol., 3, 49–60 (1981).

    PubMed  CAS  Google Scholar 

  7. M. J. Millan, A. Czkonkowski, A. Lipkowski, and A. Herz,J. Pharmacol. Exp. Ther.,251, 342–350 (1989).

    PubMed  CAS  Google Scholar 

  8. T. Podzuweit, L. H. Opie, and W. F. Lubbe,Lancet,1, 341–342 (1976).

    Article  PubMed  CAS  Google Scholar 

  9. P. F. Von Voigtlander, R. A. Lahti, and J. H. Ludes,J. Pharmacol. Exp. Ther.,224, No 1, 7–12 (1983).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Cardiology, Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk

    L. N. Maslov, A. V. Krylatov & Yu. B. Lishmanov

Authors
  1. L. N. Maslov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Krylatov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu. B. Lishmanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No 1, pp. 24–25, January, 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maslov, L.N., Krylatov, A.V. & Lishmanov, Y.B. On the involvement of endogenous μ- and δ-opiate receptor agonists in the antiarrhythmic effect of adaptation. Bull Exp Biol Med 121, 20–21 (1996). https://doi.org/10.1007/BF02445695

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445695

Key Words

Search

Navigation