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Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 5, pp 1107–1109 | Cite as

Role of transforming growth factor-β in erythroid cell-mediated suppression of B-cell blastogenesis

  • G. V. Seledtsova
  • V. I. Seledtsov
  • D. M. Samarin
  • V. Ya. Taraban
  • S. V. Sennikov
  • E. A. Kashchenko
  • V. A. Kozlov
Microbiology and Immunology

Abstract

Soluble products spontaneously secreted by murine nuclear erythroid cells directly suppress the proliferation of activated B-lymphocytes induced by bacterial lipopolysaccharides. Blocking of the transforming growth factor-β synthesis in nuclear erythroid cells by antisense oligonucleotides binding mRNA and blocking of this factor's functional activity by neutralizing antibodies were associated with a marked decrease in suppressor activity of the medium conditioned by nuclear erythroid cells.

Key Words

erythroblast natural immunosuppression transforming growth factor-β 

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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • G. V. Seledtsova
    • 1
  • V. I. Seledtsov
    • 1
  • D. M. Samarin
    • 1
  • V. Ya. Taraban
    • 1
  • S. V. Sennikov
    • 1
  • E. A. Kashchenko
    • 1
  • V. A. Kozlov
    • 1
  1. 1.Institute of Clinical ImmunologySiberian Division of Russian Academy of Medical SciencesNovosibirsk

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