Role of transforming growth factor-β in erythroid cell-mediated suppression of B-cell blastogenesis
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Soluble products spontaneously secreted by murine nuclear erythroid cells directly suppress the proliferation of activated B-lymphocytes induced by bacterial lipopolysaccharides. Blocking of the transforming growth factor-β synthesis in nuclear erythroid cells by antisense oligonucleotides binding mRNA and blocking of this factor's functional activity by neutralizing antibodies were associated with a marked decrease in suppressor activity of the medium conditioned by nuclear erythroid cells.
Key Wordserythroblast natural immunosuppression transforming growth factor-β
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