Abstract
Activation of protein kinase C (transfer from cytosol to cell membranes) with phorbol ester increases proliferation of splenic colony-forming units in the bone marrow. Subsequent incubation of bone marrow cells with the factor inhibiting proliferative activity of early hemopoietic precursors results in the recovery of protein kinase C activity in cell cytosol and a decrease in proliferative activity.
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A. J. Becker, E. A. McCulloch, L. Siminovitch, and J. E. Till,Blood,26, 296–303 (1965).
M. M. Breadford,Anal. Biochem.,72, No. 1–2, 248–254 (1976).
P. Cohen,Proc. R. Soc. Lond. [Biol.],234, No. 1275, 115–144 (1988).
A. Falus and K. Meretey,Immunol. Today,13, No. 5, 154–156 (1992).
E. Johns,Biochem. J.,92, No. 1, 55–59 (1964).
U. Kikkawa and J. Nishizuka,Annu. Rev. Cell Biol.,2, 149–160 (1986).
V. A. Kozlov, I. A. Orlovskaya, and I. G. Tsyrlova,Cell Tissue Kinet.,20, 1–6 (1987).
J. Nishizuka,Nature,308, 693–698 (1984).
A. D. Whetton, P. N. Monk, S. D. Consalvey,et al., Proc. Natl. Acad. Sci. USA,85, No. 10, 3284–3288 (1988).
J. J. Witt and R. Roskoski,Anal. Biochem.,66, 253–258 (1975).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 541–543, November, 1997
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Matrosova, V.Y., Toporkova, L.B., Orlovskaya, I.A. et al. Proliferative activity of early hemopoietic precursors under conditions of increased and decreased activity of protein kinase C in mouse bone marrow. Bull Exp Biol Med 124, 1098–1100 (1997). https://doi.org/10.1007/BF02445672
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DOI: https://doi.org/10.1007/BF02445672