Bulletin of Experimental Biology and Medicine

, Volume 124, Issue 5, pp 1075–1077 | Cite as

Effect of platinum-containing cytostatics on rat progeny

  • T. G. Borovskaya
  • M. E. Smirnova
  • E. D. Gol'dberg
General Pathology and Pathological Physiology


Pathological changes in internal organs are seen in some offspring of intact females and males treated with platidiam 1 month before mating. One case of malformation was found in the progeny of cytostatic-treated females. High embryonal mortality is noted in animals treated with cytostatics 3 and 6 months before mating. Delayed ossification is observed in some animals of almost all experiments groups.

Key Words

rat platidiam progeny 


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Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • T. G. Borovskaya
    • 1
  • M. E. Smirnova
    • 1
  • E. D. Gol'dberg
    • 1
  1. 1.Institute of Pharmacology, Tomsk Research CenterSiberian Division of the Russian Academy of Medical SciencesUSSR

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