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Protective effect of neurotensin during vagal arrhythmias

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effects of neurotensin and its analog [d-Trp11]-neurotensin were studied on Wenckebach arrhythmia and atrioventricular dissociation provoked by vagal volley stimulation. In both cases the antiarrhythmic effect of neurotensin was observed, which was mediated by activation of cardiac β-adrenoreceptors and manifested 40–60 sec after its administration. The neurotensin analog had no cardioprotective activity, but when applied before neurotensin, it demonstrated antagonism to the protective effect of natural neurotensin.

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Authors and Affiliations

  1. Department of Normal Physiology, Kuban Medical Academy, Krasnodar

    O. E. Osadchii, V. M. Pokrovskii, O. G. Kompaniets & A. N. Kurzanov

Authors
  1. O. E. Osadchii
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  2. V. M. Pokrovskii
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  3. O. G. Kompaniets
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  4. A. N. Kurzanov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 495–497, November, 1997

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Osadchii, O.E., Pokrovskii, V.M., Kompaniets, O.G. et al. Protective effect of neurotensin during vagal arrhythmias. Bull Exp Biol Med 124, 1056–1058 (1997). https://doi.org/10.1007/BF02445659

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  • DOI: https://doi.org/10.1007/BF02445659

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