Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 6, pp 1254–1257 | Cite as

Disorders in the structural and metabolic organization of liver acini in systemic endotoxemia

  • A. I. Shchegolev
  • S. P. Yavolov
  • O. D. Mishnev
Morphology and Pathomorphology


Injection ofEscherichia coli lipopolysaccharide to dogs caused pronounced structural and metabolic changes of liver acini, characterized by the development of compensatory reactions to the endotoxin followed by their failure. In addition to hypoxia, depressed activity of hepatocyte dehydrogenases and diaphorases with impairment of the intraacinar gradient of their activity, leading to the development of hepatocellular insufficiency, appears to underlie the involvement of the liver in systemic endotoxemia.

Key Words

liver acinus metabolism endotoxin 


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Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. I. Shchegolev
    • 1
  • S. P. Yavolov
    • 1
  • O. D. Mishnev
    • 1
  1. 1.Department of Pathological Anatomy, Faculty of TherapeuticsRussian State Medical UniversityMoscow

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