Bulletin of Experimental Biology and Medicine

, Volume 120, Issue 5, pp 1121–1124 | Cite as

Effects of β-casomorphin-7 on different types of learning in white rats

  • A. S. Maklakova
  • V. A. Dubynin
  • I. V. Nazarenko
  • V. N. Nezavibat'ko
  • L. A. Alfeeva
  • A. A. Kamenskii
Pharmacology and Toxicology

Abstract

The heptapeptide β-casomorphin-7, a casein fragment of cow's milk, accelerated the learning of a food-procuring habit in a T-maze by rats injected with this heptapeptide in a dose of 1 or 5 mg/kg body weight 5 min before the start of each learning session. This effect was blocked by pretreating rats with naloxone. On the other hand, β-casomorphin-7 in the indicated doses delayed learning of the active avoidance response involving the use of a painful reinforcing stimulus. The results of this study indicate that β-casomorphin-7 attenuates defense reactions by shifting the total balance of motivations toward food-procuring behavior.

Key Words

learning β-casomorphin-7 and analogs opioids naloxone 

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References

  1. 1.
    V. A. Dubynin, A. S. Maklakova, V. N. Nezavibat'ko,et al., Byull. Eksp. Biol. Med.,114, No 9, 284 (1992).Google Scholar
  2. 2.
    A. S. Maklakova, V. A. Dubynin, N. G. Levitskaya,et al., Byull. Eksp. Biol. Med.,116, No 8, 155 (1993).Google Scholar
  3. 3.
    G. Bot, L. A. Shahl, P. J. Brent,et al., Neuropharmacology,31, 825 (1992).PubMedCrossRefGoogle Scholar
  4. 4.
    V. Brantl, H. Techemacher, A. Henschen,et al., Hoppe-Seylers Z. Physiol. Chem.,360, 1211 (1979).PubMedGoogle Scholar
  5. 5.
    A. F. M. Delcampo, R. G. McMurray, G. M. Besser,et al., Biol. Psychiatry,32, 344 (1992).CrossRefGoogle Scholar
  6. 6.
    G. Grecksch, A. Becker, and H. Matthies,Naunyn Schmiedebergs Arch. Pharmacol.,342, Suppl., R11 (1990).Google Scholar
  7. 7.
    G. Koch and V. Brantl, in:Beta-Casomorphins and Related Peptides, Uppsala (1990), p. 21.Google Scholar
  8. 8.
    U. Kohler and C. Rauca,Peptides,13, 141 (1992).PubMedCrossRefGoogle Scholar
  9. 9.
    J. L. Martinez, R. V. Hernandez, and S. B. Rodriguez,Peptides,13, 885 (1992).PubMedCrossRefGoogle Scholar
  10. 10.
    M. E. Meyer,Pharmacol. Biochem. Behav.,45, 315 (1993).PubMedCrossRefGoogle Scholar
  11. 11.
    G. A. Olson, R. D. Olson, and A. J. Kastin,Peptides,11, 1277 (1990).PubMedCrossRefGoogle Scholar
  12. 12.
    M. E. Ragozzino, M. E. Parker, P. E. Gold,et al., Brain Res.,597, 241 (1992).PubMedCrossRefGoogle Scholar
  13. 13.
    H. L. Ruthrich, G. Grecksch, H. Matthies,et al., Pharmacol. Biochem. Behav.,44, 227 (1993).PubMedCrossRefGoogle Scholar
  14. 14.
    H. Stark, B. Lossner, and H. Matthies,Biomed. Biochem. Acta,46, 687 (1987).Google Scholar
  15. 15.
    D. Tome, A.-M. Dumontier, M. Hautefeuille,et al., Amer. J. Physiol.,253, G737 (1987).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • A. S. Maklakova
    • 1
    • 2
  • V. A. Dubynin
    • 1
    • 2
  • I. V. Nazarenko
    • 1
    • 2
  • V. N. Nezavibat'ko
    • 1
    • 2
  • L. A. Alfeeva
    • 1
    • 2
  • A. A. Kamenskii
    • 1
    • 2
  1. 1.Moscow State UniversityMoscow
  2. 2.Institute of Molecular Genetics, Russian Academy of SciencesMoscow State UniversityMoscow

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