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Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin

  • Oncology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Somatoliberin stimulates secretion of growth hormone and has no effect on secretion of prolactin in primary cultures of hypophyseal adenoma cells obtained from acromegalic patients. A short-term contact of the cells with somatostatin inhibits secretion of growth hormone, while a long-term contact with this hormone inhibits prolactin production. Somatoliberin abolishes the inhibitory effect of somatostatin on the growth hormone secretion and at high concentrations stimulates it.

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 323–326, March, 1997

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Komolov, I.S., Bulatov, A.A., Osipova, T.A. et al. Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin. Bull Exp Biol Med 123, 279–282 (1997). https://doi.org/10.1007/BF02445426

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  • DOI: https://doi.org/10.1007/BF02445426

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