Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 3, pp 279–282 | Cite as

Secretory reactions of cultured hypophyseal growth hormone-producing adenoma cells to somatoliberin and somatostatin

  • I. S. Komolov
  • A. A. Bulatov
  • T. A. Osipova
  • G. P. Elizarova
  • S. Yu. Serpukhovitin
  • S. Yu. Kasumova
Oncology

Abstract

Somatoliberin stimulates secretion of growth hormone and has no effect on secretion of prolactin in primary cultures of hypophyseal adenoma cells obtained from acromegalic patients. A short-term contact of the cells with somatostatin inhibits secretion of growth hormone, while a long-term contact with this hormone inhibits prolactin production. Somatoliberin abolishes the inhibitory effect of somatostatin on the growth hormone secretion and at high concentrations stimulates it.

Key Words

hypophyseal adenoma growth hormone prolactin somatoliberin somatostatin cell cultures 

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References

  1. 1.
    A. A. Bulatov, I. S. Komolov, N. B. Smirnova,et al., Byull. Eksp. Biol. Med.,113, No. 4, 406–409 (1992).Google Scholar
  2. 2.
    I. S. Komolov, A. A. Bulatov, E. E. Makarovskaya,et al., —Ibid.,,118, No. 11, 543–546 (1994).Google Scholar
  3. 3.
    I. S. Komolov, A. A. Bulatov, Yu. K. Trunin,et al., —Ibid.,,113, No. 4, 421–424 (1992).CrossRefGoogle Scholar
  4. 4.
    A. L. Baldvin, R. Aston, J. Butler,et al., Acta Endocrinol. (Copenh.),119, No. 3, 326–332 (1988).Google Scholar
  5. 5.
    A. L. Barkan, Y. Shenker,et al., J. Clin. Endocrinol.,63, 1057–1064 (1986).Google Scholar
  6. 6.
    N. E. Cooke, D. Coit, K. I. Baxter,et al., J. Biol. Chem.,256, 4007–4016 (1981).PubMedGoogle Scholar
  7. 7.
    Z. Dickerman, H. Guyda, and G. S. Tannenbaum,J. Clin. Endocrinol. Metab.,73, No. 3, 652–657 (1993).CrossRefGoogle Scholar
  8. 8.
    L. J. Hofland, P. M. van Koetsveld, C. C. J. van Vroonhoven,et al., —Ibid.,,68, No. 3, 613–620 (1989).PubMedGoogle Scholar
  9. 9.
    E. K. Horvath, D. M. Kovacs, H. S. Killinger,et al., Virchows Arch. [A],398, 277 (1983).CrossRefGoogle Scholar
  10. 10.
    M. Ishibashi and T. Yamaji,J. Clin. Endocrinol.,60, No. 5, 985–993 (1985).CrossRefGoogle Scholar
  11. 11.
    D. Joubert, B. Mouhieddine, C. Benlot,et al., Horm. Res.,38, No. 1-2, 100–104 (1992).PubMedCrossRefGoogle Scholar
  12. 12.
    R. M. McLeod and A. Abad,Endocrinology,83, No. 4, 799–806 (1968).Google Scholar
  13. 13.
    J. C. Reubi, P. U. Heitz, and A. M. Landolf,J. Clin. Endocrinol.,65, 65 (1987).Google Scholar
  14. 14.
    H. Soya and M. Suzuki,Endocrinology,126, No. 1, 285–291 (1990).PubMedCrossRefGoogle Scholar
  15. 15.
    I. Wakabayashi, K. Inokuchi, O. Hasegava,et al., J. Clin. Endocrinol. Metab.,74, No. 2, 357–361 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • I. S. Komolov
    • 1
  • A. A. Bulatov
    • 1
  • T. A. Osipova
    • 1
  • G. P. Elizarova
    • 1
  • S. Yu. Serpukhovitin
    • 1
  • S. Yu. Kasumova
    • 1
  1. 1.Endocrinology Research CenterRussian Academy of Medical SciencesMoscow

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