Bulletin of Experimental Biology and Medicine

, Volume 123, Issue 3, pp 251–254 | Cite as

Changes in blood content of prostaglandin F and leukotrienes C4 and B4 in rats after intravenous injection of contrast agents

  • P. V. Sergeev
  • Yu. K. Napolov
  • E. V. Markina
  • E. N. Bolotova
  • N. L. Shimanovskii
Pharmacology and Toxicology


It is shown that Triombrast=Hexabrix=Omnipaque≤Melitrast<Ultravist in a dose-independent manner increase the level of prostaglandin F and leukotrienes C4 and B4 in the blood of sensitive rats (50%) 15 min after intravenous injection of the preparation, the changes in prostaglandin F being maximal, while those in leukotrienes C4 minimal. The effect of nonionic contrast agents on the blood level of prostaglandin F (0.1–2.0 g I/kg, except for Omnipaque) and leukotriene B4 (in a dose of 0.5 g I/kg) is more pronounced in comparison with the ionic preparations.

Key Words

contrast agents eicosanoids 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • P. V. Sergeev
    • 1
  • Yu. K. Napolov
    • 1
  • E. V. Markina
    • 1
  • E. N. Bolotova
    • 1
  • N. L. Shimanovskii
    • 1
  1. 1.Department of Molecular PharmacologyRussian State Medical UniversityMoscow

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