Skip to main content
SpringerLink
Log in

Effect of the hydra peptide morphogen on posthypoxic disorders in rats exposed to prenatal hypoxia

  • General Pathology and Pathological Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Lipid peroxidation in the lungs and blood are activated while DNA synthesis in the tracheal epithelium and hepatocytes is inhibited during the first five days of postnatal life in rat pups after severe prenatal hypoxia. Intraperitoneal injection of the undecapeptide pGlu-Pro-Pro-Glu-Glu-Ser-Lys-Val-Ile-Leu-Phe, a peptide morphogen isolated from the hydra, before hypoxia normalizes lipid peroxidation in the lungs and blood of the five-day-old pups. A compensatory activation of DNA synthesis occurs in tracheal epithelium and hepatocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. V. Vdovenko and S. S. Timoshin,Byull. Eksp. Biol. Med.,96, No. 8, 87–88 (1983).

    Google Scholar 

  2. V. B. Gavrilov and N. I. Mishkorudnaya,Lab. Delo, No. 3, 33–36 (1983).

    Google Scholar 

  3. O. A. Gomazkov,Functional Biochemistry of Regulatory Peptides [in Russian], Moscow (1992).

  4. G. M. Kalivetskaya, S. S. Timoshin, A. L. Lykov,et al., Byull. Eksp. Biol. Med.,93, No. 4, 92–94 (1982).

    Article  Google Scholar 

  5. O. A. Lebed'ko and S. S. Timoshin,Byull. Eksp. Biol. Med. 117, No. 5, 531–533 (1994).

    Google Scholar 

  6. O. A. Lebed'ko and S. S. Timoshin, —Ibid., pp. 535–538.

    Google Scholar 

  7. F. Z. Meerson and V. K. Vasil'ev,Vopr. Med. Khimii, No. 2, 115–117 (1982).

    Google Scholar 

  8. T. N. Fedorova, T. S. Korshunova, and S. G. Larskii,Lab. Delo, No. 3, 25–27 (1983).

    Google Scholar 

  9. A. Yu. Khomichuk and S. S. Timoshin,Byull. Eksp. Biol. Med.,112, No. 9, 307–308 (1991).

    CAS  Google Scholar 

  10. L. D. Hansen and W. T. Wariorick,Am. J. Clin. Pathol.,46, 117 (1966).

    Google Scholar 

  11. C. Niedenzu, K. Grasedyck, N. Voelkek,et al., Int. Arch. Occup. Environ. Health.,48, 185–193 (1981).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Maternity and Child Protection, Siberian Division of the Russian Academy of Medical Sciences, Khabarovsk

    O. A. Lebed'ko, T. V. Yatsenko, S. S. Timoshin & A. Yu. Rubina

Authors
  1. O. A. Lebed'ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. Yatsenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. S. Timoshin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Yu. Rubina
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 269–272, March, 1997.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lebed'ko, O.A., Yatsenko, T.V., Timoshin, S.S. et al. Effect of the hydra peptide morphogen on posthypoxic disorders in rats exposed to prenatal hypoxia. Bull Exp Biol Med 123, 232–234 (1997). https://doi.org/10.1007/BF02445411

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02445411

Key Words

Search

Navigation