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Bridges and multipolar mitoses in populations of rat PA-23 rhabdomyosarcoma cells

  • Oncology
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Abstract

Frequencies of abnormal mitoses are estimated in clones (experimental metastases) of two sublines of transplanted rat PA-23 rhabdomyosarcoma selected for increased and decreased frequency of bridges. It is shown that the frequency of cells with bridges is associated with a wide range abnormal mitoses and reflects the incidence of structural chromosomal and genomic mutations in the malignant cell populations.

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Authors and Affiliations

  1. Research Center of Clinical Radiology, Academy of Military Medicine, St. Petersburg

    V. Yu. Kravtsov, S. N. Proshin, A. F. Yakovlev, E. V. Kaminskaya & Yu. B. Vakhtin

  2. Laboratory of Molecular Cytogenetics, All-Russian Institute of Animal Genetics and Breeding, Russian Academy of Agricultural Sciences, St. Petersburg

    V. Yu. Kravtsov, S. N. Proshin, A. F. Yakovlev, E. V. Kaminskaya & Yu. B. Vakhtin

  3. Laboratory of Cell Population Genetics, Institute of Cytology, Russian Academy of Sciences, St. Petersburg

    V. Yu. Kravtsov, S. N. Proshin, A. F. Yakovlev, E. V. Kaminskaya & Yu. B. Vakhtin

Authors
  1. V. Yu. Kravtsov
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  2. S. N. Proshin
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  3. A. F. Yakovlev
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  4. E. V. Kaminskaya
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  5. Yu. B. Vakhtin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 569–572, May, 1997

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Kravtsov, V.Y., Proshin, S.N., Yakovlev, A.F. et al. Bridges and multipolar mitoses in populations of rat PA-23 rhabdomyosarcoma cells. Bull Exp Biol Med 123, 496–498 (1997). https://doi.org/10.1007/BF02445330

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  • DOI: https://doi.org/10.1007/BF02445330

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