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The “graft versus leukemia” effect under conditions of mixed chimeric hemopoiesis

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The “graft versus leukemia” effect can be induced in (C57B1/6×DBA) F1 mice by two transplantations of cell suspensions containing bone marrow cells and splenocytes of (CBA×C57B1/6) F1 mice and an injection of cyclophosphamide. The recipients of cell allotransplants were characterized by mixed chimeric hemopoiesis. These data outline a new approach to induction of the graft versus leukemia effect, requiring no complete elimination of the recipient's hemopoiesis and characterized by a low probability of lethal graft-versus-host reaction.

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Authors and Affiliations

  1. Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk

    G. V. Seledtsova, V. I. Seledtsov, I. V. Avdeev, D. M. Samarin & V. A. Kozlov

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  1. G. V. Seledtsova
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  2. V. I. Seledtsov
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  3. I. V. Avdeev
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  4. D. M. Samarin
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  5. V. A. Kozlov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 562–565, May, 1997

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Seledtsova, G.V., Seledtsov, V.I., Avdeev, I.V. et al. The “graft versus leukemia” effect under conditions of mixed chimeric hemopoiesis. Bull Exp Biol Med 123, 490–492 (1997). https://doi.org/10.1007/BF02445328

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  • DOI: https://doi.org/10.1007/BF02445328

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