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Mechanisms of regulation of lysosomal thiol protease activity in thyroid gland: Effects of protein synthesis inhibitors

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Triiodothyronine administered for 7 days reduces the contents of total cathepsin B and L (but not cathepsin C) in rat thyroid gland. Cycloheximide reduces the contents of cathepsin B, C, and L, while actinomycin D induces a less pronounced decrease in cathepsin C and L activity, cathepsin B activity being unchanged. Against the background of triiodothyronine, both agents equally inhibit these proteases.

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Authors and Affiliations

  1. Department of Biological and Bioorganic Chemistry, I. P. Pavlov Medical University, Ryazan

    E. A. Stroev & M. Yu. Kochukov

Authors
  1. E. A. Stroev
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  2. M. Yu. Kochukov
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 5, pp. 521–523, May, 1997

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Stroev, E.A., Kochukov, M.Y. Mechanisms of regulation of lysosomal thiol protease activity in thyroid gland: Effects of protein synthesis inhibitors. Bull Exp Biol Med 123, 453–455 (1997). https://doi.org/10.1007/BF02445316

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  • DOI: https://doi.org/10.1007/BF02445316

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