The role of heart vegetative nerves in antiarrhythmic effect of β-endorphin in experimental myocardial ischemia

  • S. D. Mikhailova
  • G. I. Storozhakov
  • N. A. Bebyakova
  • T. M. Semushkina
General Pathology and Pathological Physiology


Acute experiments on narcotized cats showed that premedication with β-endorphin promotes the development of ventricular tachycardia and decreases the occurrence of ventricular fibrillation caused by myocardial ischemia. The antifibrillatory effect of β-endorphin is related to central nervous structures regulating the function of the cardiovascular system and is mediated through the vagus nerves.

Key Words

β-endorphin myocardial ischemia cardiac arrhythmias vagus nerves stellate ganglia 


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • S. D. Mikhailova
    • 1
  • G. I. Storozhakov
    • 1
  • N. A. Bebyakova
    • 1
  • T. M. Semushkina
    • 1
  1. 1.Russian State Medical UniversityMoscow

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